Key to skin regeneration? Menard study identifies diglycerides as crucial to skin stem cell growth

Menard has previously established the efficacy of sweet cherry (Prunus avium) seed extract and its ability to stimulate skin stem cell growth.

“Menard has previously discovered that a decrease in skin stem cells leads to skin ageing such as dryness, wrinkles, and sagging. In addition, we have found that an extract extracted from the seeds of sweet cherry has the effect of increasing epidermal stem cells.”

This study aimed to delve deeper to isolate the specific active compound that increased skin stem cells.

Through a detailed analysis, researchers identified diglycerides, a fatty acid ester, as the component that was responsible for increasing stem cells.

Part of this research was presented at the 34th International Federation of Societies of Cosmetic Chemists (IFSCC) Academic Conference held October 14 to 17, in Brazil.

To further validate its findings, the team conducted experiments using 3D cultured epidermis models.

In one model with added diglycerides, the team observed enhanced epidermal formation and thickness as compared to the model without diglycerides.

Additionally, the study utilised LC-OCT, a technology it developed that can non-invasively image the internal structure of the skin with aid from artificial intelligence.

“Menard has previously developed technology to visualize epidermal stem cells inside the skin by analysing images obtained by LC-OCT with proprietary AI. This time, we have rebuilt the AI ​​algorithm and evolved it into a system that can detect epidermal stem cells with greater sensitivity.”

The researchers developed an ingredient rich in diglycerides and analysed epidermal stem cells before and after three months of using a formulation containing this ingredient.

“As a result, we confirmed that the number of epidermal stem cells had increased after three months of use. Furthermore, we confirmed that the epidermis had thickened, suggesting that this ingredient promotes skin regeneration.”

Future research and product development

This discovery reinforces Menard's prior research that a decrease in skin stem cells contributes to ageing. This includes factors such as dryness, wrinkles, and sagging.

By identifying a specific compound that promotes stem cell growth, the firm see potential to develop effective anti-ageing solutions that address the root cause of skin deterioration.

It paves the way for developing skin care products that effectively target skin ageing by directly boosting skin stem cell population, leading to skin regeneration and a more youthful appearance.

Moving forward, the company said it will further the research to understand the mechanism of action of diglycerides on skin stem cells.

It also said it would develop skin care with diglycerides and validate its efficacy and safety through clinical trials.